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Updated: Jul 16, 2025

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

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第一个强大的宏观循环A3腺素受体激动剂揭示了G-蛋白和β-阿雷斯2信号偏好

Dilip K Tosh1, Courtney L Fisher2, Veronica Salmaso1,3

  • 1Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.

ACS pharmacology & translational science
|September 14, 2023
PubMed
概括

合成了新的宏环腺素受体激活剂,显示出改变的信号通路和增强的Gαi2合. 这些化合物为设计具有独特药理特征的选择性A3腺素受体激动剂提供了新的途径.

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