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对于α-gal敏感性高风险群体

Marie Benders-Guedj¹, Martin Köberle¹, Heidelore Hofmann¹

¹Department of Dermatology and Allergy Biederstein, Faculty of Medicine, Technical University of Munich, Munich, Germany.

Allergologie select

|September 14, 2023

概括

经常的咬增加了银河糖α-1,3-银河糖 (α-gal) 敏感化的风险,特别是在猎人和林业工作者中. 这种与IgE抗体相关的敏感性可能已经存在了几十年.

科学领域:

免疫学免疫学免疫学
过敏学过敏学
流行病学流行病学

背景情况:

咬引起的IgE介导反应对银河糖α-1,3-银河糖 (alpha-gal) 是一个越来越令人担忧的问题.
这项研究调查了不同咬暴露水平的α-gal敏感性.

研究的目的:

评估莱姆病症患者的α-gal敏感化患病率,并将其与对照组进行比较.
评估高暴露个体的α-gal敏感性,如狩猎者和森林工作者.

主要方法:

对α-gal和总IgE的特定IgE (sIgE) 抗体被测量在485名莱姆病患者和200名对照组中.
此外,还分析了232名猎人和林业工人,他们被认为经常被咬.

主要成果:

在12.6%的波雷里病患者中发现了α-gal sIgE,而在对照组中 (不显著) 发现了9%.
猎人和林业工作者表现出明显更高的alpha-gal sIgE流行率 (22.8%,p < 0.001).
较高的年龄和较高的总IgE与α-gal敏感性相关.

结论:

暴露于的个体,特别是那些患有病的人,表现出更高的α-gal敏感度的趋势.
经常的接触是对α-gal敏感性的可能驱动因素.
慕尼黑的流行率似乎低于其他地区,可能是由于物种或暴露频率;α-gal敏感性不是一个新的现象.

关键词:

阿尔法-敏感化波雷里病是一种病.的联系方式的联系方式

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