机器学习模型的开发和验证用于静脉血栓塞栓症在入院时的风险评估:一个回顾性研究
Wenbo Sheng1, Xiaoli Wang2, Wenxiang Xu1
1Research and Development Department, Shanghai Synyi Medical Technology Co., Ltd., Shanghai, China.
Frontiers in cardiovascular medicine
|September 14, 2023
概括
与Caprini风险评分相比,机器学习模型显著改善了入院时静脉血栓栓塞 (VTE) 风险预测. 随机森林模型在早期VTE查和预防方面表现出卓越的性能.
科学领域:
- 医疗信息学 医疗信息学
- 临床预测模型临床预测模型
- 医疗保健中的机器学习
背景情况:
- 在入院时进行静脉血栓栓塞 (VTE) 风险评估对于有效的患者管理至关重要.
- 目前的风险评估工具可能缺乏最佳的预测准确性.
研究的目的:
- 开发和验证新的机器学习 (ML) 模型,用于在招生时预测VTE风险.
- 将ML模型的性能与已建立的卡普里尼风险评分 (CRS) 进行比较.
主要方法:
- 一项涉及3078个人的回顾性研究.
- 后勤回归 (LR),随机森林 (RF) 和极端梯度增强 (XGB) 模型的开发.
- 使用AUROC,AUPRC和净重新分类改进 (NRI) 指标进行验证.
主要成果:
- 包括LR,RF和XGB在内的ML模型在预测VTE风险方面明显优于CRS (AUROC:0.798-0.804vs0.714).
- 随机森林模型显示了最高的预测性能 (AUROC: 0.804,AUPRC: 0.360).
- 射频提供了更实用的风险分层,错误阳性较少,较大的低风险群体.
结论:
- 与卡普里尼风险评分相比,机器学习模型在入院时提供了更好的VTE风险预测.
- 随机森林模型表现出卓越的性能和在VTE管理中临床应用的重大潜力.
相关概念视频
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
14
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
14
Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
Venous Thrombosis I: Introduction
12
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
12
Venous Thrombosis IV: Nursing Management
14
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
14
Varicose Veins II: Diagnostic Studies and Interprofessional Care
15
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
15
Venous Return
5.1K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
5.1K


