治疗模式,坚持,坚持和医疗保健资源利用在巨病:一个现实世界的分析
Maria Fleseriu1, Ariel Barkan2, Thierry Brue3
1Pituitary Center, Departments of Medicine and Neurological Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
Journal of the Endocrine Society
|September 14, 2023
概括
现实世界中的壮症治疗表明,第一代体静止素受体配体 (SRL) 和生长激素受体对抗剂 (GHRA) 提供了比多巴胺激动剂 (DA) 更好的持久性. 更多的并发病与更高的医疗保健利用率相关.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 巨症的治疗是多式的,包括体静止素受体连接体 (SRL),多巴胺激动剂 (DA) 和生长激素受体对抗剂 (GHRA).
- 有限的近期现实世界的证据存在于巨治疗模式.
研究的目的:
- 为了评估药物使用,治疗变化,坚持,持久性,并发病症和壮病患者的医疗资源利用情况.
- 基于真实世界的数据,为个性化治疗建议提供见解.
主要方法:
- 分析来自MarketScan美国索赔数据库的非身份化数据.
- 包括882名接受单一治疗或组合治疗的患者,治疗时间≥90天,没有治疗间隙.
主要成果:
- 大多数患者 (94.6%) 开始单一治疗,最常见的是卡伯戈林 (DA),八类LAR (SRL) 和兰类仓库 (SRL).
- 第一代SRL显示了较高的坚持 (0.8) 与DAs (0.7) 相比.
- 在GHRAs (24.8个月) 和第一代SRLs (20.0个月) 与DAs (14.4个月) 之间,治疗持续时间更高.
结论:
- 现实世界的数据显示,不同壮病药物之间的治疗持久性和坚持性各不相同.
- 增加的并发病与更高的医疗保健访问有关,这表明疾病负担更大.
- 研究结果支持在壮病管理中需要个性化治疗策略.
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