斋月间歇性禁食对肠道微生物群的影响:饮食是关键吗?
Duygu Saglam1, Gozde Aritici Colak1, Eray Sahin2
1Department of Nutrition and Dietetics, Health Sciences Faculty, Acibadem Mehmet Ali Aydinlar University, Istanbul, Türkiye.
Frontiers in microbiology
|September 14, 2023
概括
斋月间歇性禁食显著改变了肠道微生物群的组成,减少了像Firmicutes这样的有益细菌,增加了像Proteobacteria这样的潜在有害细菌. 饮食选择也影响了微生物平衡,强调了食物类型和禁食时间的作用.
科学领域:
- 微生物学与人类健康
- 营养科学和肠道微生物组研究
背景情况:
- 饮食显著影响肠道微生物群的组成.
- 间歇性禁食对肠道微生物群的具体影响,例如在斋月期间,仍然在很大程度上不清楚.
研究的目的:
- 调查斋月期间间歇性禁食对健康成年人肠道微生物群的影响.
- 探索饮食摄入量与细菌品种丰富度的变化之间的相关性.
主要方法:
- 在斋月禁食29天 (17小时/天) 中观察到12名健康成年人.
- 在研究开始和结束时通过3天记录评估饮食摄入量.
- 用16S rRNA基因测序分析肠道微生物群,用于属级分类学注释.
主要成果:
- 禁食显著降低了Firmicutes的丰富度,增加了蛋白质细菌的丰富度 (p < 0.05).
- 七个细菌系 (例如,布劳蒂亚,Coprococcus) 的数量减少,而Escherichia和Shigella的数量增加.
- 在特定的属和饮食成分之间发现了负相关性:Ihubacter/蛋白质,Fusicatenibacter/蔬菜,Intestinibacter/坚果.
结论:
- 斋月间歇性禁食显著重塑肠道微生物的组成.
- 饮食习惯,包括消费的食物类型,在调节肠道微生物群方面发挥着至关重要的作用,即使是持续的禁食模式.
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