看到SARS-CoV-2和SARS-CoV的T细胞免疫力:相信以位为导向的疫苗
Can Yue1, Pengyan Wang2, Jinmin Tian3,4
1CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS), Beijing, China.
International journal of biological sciences
|September 14, 2023
概括
这项研究分析了SARS-CoV-2的T细胞表位及其结构,发现保存的对疫苗开发和与SARS-CoV潜在的交叉免疫至关重要. 这些发现凸显了T细胞表位为下一代疫苗的前景.
科学领域:
- 免疫学和疫苗学 免疫学和疫苗学
- 结构生物学 结构生物学
- 病毒免疫学 病毒免疫学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 的出现促使对免疫反应进行了广泛的研究.
- 幽默免疫和细胞免疫,特别是涉及T细胞表位的T细胞反应,对于病毒清除至关重要.
- 了解T细胞表位是开发针对SARS-CoV-2的有效疫苗的关键.
研究的目的:
- 从蛋白质数据库 (PDB) 总结SARS-CoV-2 T细胞表位的可用的/主要基因相容性复合体 (pMHC) 结构.
- 探索在未来的SARS-CoV-2疫苗开发中利用T细胞表位的挑战和机会.
- 为了研究SARS-CoV和SARS-CoV-2之间潜在的T细胞交叉免疫力.
主要方法:
- 从PDB中检索和分析了27个SARS-CoV-2相关的pMHC结构和5个T细胞受体综合体.
- 在SARS-CoV-2蛋白质 (Spike,Nucleocapsid,ORF1ab) 中确定了T细胞表位的分布.
- 检查了人白细胞抗原 (HLA) 与SARS-CoV表位组合的结构,以获得交叉免疫洞察力.
主要成果:
- 大多数已识别的SARS-CoV-2 T细胞表位在关注的变体中保存,其中一些突变发生在Spike蛋白中.
- 结构分析显示了SARS-CoV和SARS-CoV-2之间的潜在交叉T细胞免疫力.
- 该研究通过对抗原的结构研究来可视化T细胞交叉免疫机制.
结论:
- T细胞表位结构提供了对抗SARS-CoV-2的免疫反应的见解.
- 保存的T细胞表位为下一代疫苗开发提供了一个有希望的目标.
- 对针对SARS-CoV-2的T细胞表位面向疫苗进行进一步的研究是有必要的.
关键词:
在 COVID-19 疫情中,上层层是什么意思 上层是什么意思这就是SARS-CoV-2病毒.萨尔贝科病毒是一种病毒.在TCR中,可以使用TCR.疫苗 疫苗 疫苗 疫苗在pMHC中,pMHC是更多相关视频
00:10Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
Published on: August 21, 2019
7.6K
05:15Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay
Published on: February 10, 2022
3.7K
相关概念视频
Cross-reactivity
31.2K
Overview
31.2K
Vaccinations
44.7K
Overview
44.7K
Conjugated Proteins
18.4K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.4K
Cancer Vaccines
399
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
399
Antigens Involved in Adaptive Immunity
536
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
536
Tumor Immunotherapy
554
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
554
