结质瘤中瘤微环境的演变及其对向治疗的含义
Yang Hu1, Zhixing Li1, Yichi Zhang1
1The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, 510182, China.
International journal of biological sciences
|September 14, 2023
概括
本综述探讨了质瘤中复杂的瘤微环境 (TME),强调其矛盾的作用以及使用小鼠模型来研究TME进化和开发新疗法.
科学领域:
- 神经瘤学神经瘤学
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 质瘤是在支持瘤细胞生长的复杂瘤微环境 (TME) 中发展的.
- 质瘤TME由多种细胞组成,包括大脑居民,免疫和血管细胞,复杂的相互作用驱动TME进化.
研究的目的:
- 审查质瘤TME的双重作用.
- 总结最近在小鼠模型中研究TME演变的进展.
- 概述TME向质瘤的新兴治疗策略.
主要方法:
- 文献综述侧重于质瘤TME.
- 在TME研究中分析小鼠模型的实用性.
- 综合当前针对TME的治疗方法.
主要成果:
- 在质瘤的进展和治疗反应中,TME起着矛盾的作用.
- 鼠标模型对于理解TME动态和测试疗法至关重要.
- 在开发针对质瘤TME的治疗方法方面取得了重大进展.
结论:
- 了解复杂的质瘤TME对于有效治疗至关重要.
- 鼠标模型为TME进化和治疗干预提供了宝贵的见解.
- 向TME代表了质瘤治疗策略的一个有希望的前沿.
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