代谢综合征,过和长期GFR下降之间的关联 在一般人群中
Erikka W Bystad1, Vidar T N Stefansson1,2, Bjørn O Eriksen1,2
1Metabolic and Renal Research Group, UiT-The Arctic University of Norway, Tromsø, Norway.
Kidney international reports
|September 14, 2023
概括
代谢综合征 (MetS) 与过和成年人功能下降的速度更快有关. 针对高过的早期干预可能有助于在患有MetS的个体中保持淋巴细胞过率 (GFR).
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 代谢综合征 (MetS) 影响全球四分之一的成年人,增加糖尿病,慢性病 (CKD) 和心血管疾病的风险.
- 在一般人群中,MetS,过和长期膜过率 (GFR) 降低之间的关系尚不清楚.
研究的目的:
- 在一般的非糖尿病人群中,研究MetS,过和GFR下降率在11年内之间的关联.
主要方法:
- 脏IOhexol清除率调查 (RENIS) 包括1551名参与者 (年龄在50-63岁),没有先前存在的糖尿病,心血管或脏疾病.
- 在基线和两次随访期间,通过iohexol清除量测量了GFR. 过被定义为90百分点以上的GFR,调整为性别,年龄和身高.
- MetS是由腰围增加加上两个危险因素 (高血压,高血糖,高甘油三,或低的高密度胆固醇) 定义的. 使用线性混合模型分析了GFR下降率.
主要成果:
- MetS与基线过显著相关 (OR 2.4;P < 0.001).
- 与没有MetS的个体相比,患有MetS和过的个体表现出更的GFR下降率 (-0.83毫升/分钟/1.73米2/年).
- 在那些有MetS但没有过的人群中,观察到更急的GFR下降趋势 (-0.15毫升/分钟/1.73米2/年).
结论:
- 在一般的非糖尿病人群中,MetS与过率的增加和长期加速的GFR下降有关.
- 需要进行进一步的研究,包括随机对照试验,以确定治疗过是否可以预防MetS患者的GFR损失.
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