在新生儿急性损伤后的神经发育非常早产儿童
Chih-Chia Chen1,2, Chi-Hsiang Chu3, Yung-Chieh Lin2
1Graduate Institute of Clinical Medicine, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.
Kidney international reports
|September 14, 2023
概括
新生儿寡性急性损伤 (AKI) 与非常早产婴儿头部生长不良和神经发育问题有关. 长期监测头部尺寸和发育对于这些孩子来说至关重要.
科学领域:
- 新生儿科学 新生儿科学
- 儿科脏病学 儿科脏病学
- 发育儿科 发育儿科
背景情况:
- 新生儿急性损伤 (AKI) 影响非常早产的婴儿,可能会影响长期的结果.
- 了解不同类型的AKI (寡度与非寡度) 的具体影响对于有针对性的干预至关重要.
研究的目的:
- 为了评估头周长 (HC) 增长和神经发育结果在非常早产的婴儿后新生儿AKI.
- 为了比较新生儿与寡度AKI,非寡度AKI和没有AKI之间的结果.
主要方法:
- 在2008年至2020年期间,对732名非常早产新生儿 (妊娠31周以下) 进行了纵向随访.
- 根据尿液输出,AKI被分类为nonoliguric或oliguric.
- 死亡率,HC z-score (zHC) 在相当年龄和6,12,24个月,以及24个月的神经发育结果的比较.
主要成果:
- 寡性AKI,而不是非寡性AKI,在相当年龄时与较低的zHC有关.
- 寡头AKI组显示小头症的发病率在24个月内更高.
- 寡头性AKI独立地与增加的死亡率和神经发育障碍有关 (aOR 8.97).
结论:
- 新生儿寡性AKI是非常早产儿神经发育障碍的重要危险因素.
- 长期的头部尺寸和神经发育随访对于新生儿AKI的早产婴儿至关重要.
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