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在多民族人口中,功能和末期病和死亡的长期风险
Suping Ling1,2,3, Gang Xu4, Francesco Zaccardi1,2
1Leicester Real World Evidence Unit, Leicester Diabetes Centre, Leicester General Hospital, University of Leicester, Leicester, UK.
Kidney international reports
|September 14, 2023
概括
南亚人死亡率低于白人,但结尾期病 (ESKD) 发病率相似. 需要进一步的研究来了解病结果中的这些种族差异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 南亚和白人人口之间末期病 (ESKD) 和死亡率的种族差异没有得到充分的记录.
- 了解这些差异对于公平的医疗保健和慢性病 (CKD) 患者的治疗结果至关重要.
研究的目的:
- 为了比较南亚人和白人之间的ESKD发病率和全因死亡率.
- 为了研究基线估计的淋巴细胞过率 (eGFR) 对跨种族群体的这些结果的影响.
主要方法:
- 使用临床实践研究数据链 (CPRD) 数据的回顾性队列研究.
- 包括40,888名南亚人和236,634名随机选择的白人,在2006年1月1日之后进行eGFR测量.
- 分析所有原因死亡率和ESKD发病率,并使用使用Cox比例危险模型计算调整的危险比率 (HRs).
主要成果:
- 与白人相比,南亚人表现出较低的全因死亡率.
- 与白人女性相比,在70-85岁的南亚女性中观察到略高的ESKD发病率.
- 针对死亡率的调整HR在南亚人中较低,而针对ESKD发病率的HR在各族群中相似,无论基线eGFR如何.
结论:
- 南亚人经历的死亡率明显低于白人.
- 与白人相比,南亚人中的ESKD发病率并不大大高于白人.
- 需要进一步的研究,以阐明这些种族变异背后的机制及其对CKD管理的影响.
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