乳酸脱酶对长期COVID症状持续性的贡献:综合分析
Raphael Udeh1, Alberto Utrero-Rico2, Xenia Dolja-Gore3
1School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales, Australia.
Reviews in medical virology
|September 14, 2023
概括
在COVID-19幸存者的乳酸脱酶 (LDH) 水平升高与COVID-19 (PASC) 的呼吸系统后急性后果有关. 这种生物标志物可能有助于预测呼吸道并发症,但不能预测其他PASC域.
科学领域:
- 生物化学 生物化学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 长期COVID,或COVID-19 (PASC) 后急性后续症,提出了一个重大的临床挑战,迫切需要可靠的风险预测器.
- 乳酸脱酶 (LDH) 是由受损细胞释放的酶,正在被研究为各种疾病的潜在生物标志物.
研究的目的:
- 评估血LDH水平与PASC的存在和特定域之间的关联.
- 确定LDH是否可以作为不同PASC表现的预测生物标志物.
主要方法:
- 进行了一项全面的元分析,搜索PubMed,EMBASE,Web of Science和Google Scholar,查找到2023年3月之前发表的相关研究.
- 来自46项涉及8289名参与者的研究数据 (3338名PASC,4951名对照) 用随机效应元分析来分析,以计算标准化平均差异 (SMD).
主要成果:
- 血LDH升高与呼吸道PASC (Resp-PASC) 有显著的关联 (SMD = 1.07,p = 0.01).
- 在升高的LDH和心血管PASC (心血管PASC),神经PASC (神经PASC) 或胃肠PASC之间没有发现显著的关联.
结论:
- 高血LDH是长期COVID中呼吸道并发症的潜在预测生物标志物.
- 在COVID-19感染后的LDH升高可能作为一种有价值的疾病生物标志物,特别是用于预测Resp-PASC.
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