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Updated: Jul 16, 2025

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这条TGFβ→TAK1→LATS→YAP1路径调节了YAP1的时空动态

Min-Kyu Kim1,2, Sang-Hyun Han1,2, Tae-Geun Park1

  • 1Department of Biochemistry, College of Medicine and Institute for Tumour Research, Chungbuk National University, Cheongju 28644, Korea.

Molecules and cells
|September 14, 2023
PubMed
概括

转化生长因子β (TGFβ) 通过TAK1激活Hippo通路,导致YAP1酸化和核复合体形成. 这种新发现的TGFβ-TAK1-LATS1/2-YAP1级联调节细胞反应,并且在癌症中经常受到干扰.

关键词:
在LATS1/2在RUNX3中使用RUNX3这就是TAK1的意义.在TGFβ中,TGFβ是TGFβ.一个YAP1一个YAP1限制点是指限制点.

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