英国少数民族群体的左心室缩和死亡率:e-ECHOES研究
Eduard Shantsila1,2, Alena Shantsila2, Nefyn Williams1,2
1Department of Primary Care and Mental Health, University of Liverpool.
Journal of hypertension
|September 14, 2023
概括
高血压在英国的南亚和非洲-加勒比海社区非常普遍,而且往往没有被诊断出来. 左心室缩 (LVH) 是常见的,并且与这些人群的死亡率增加有关.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 高血压是一个主要可修改的心血管风险因素,但其患病率和影响,特别是左心室缩 (LVH),在英国的南亚和非洲-加勒比社区仍未得到充分研究.
- 高血压中目标器官损伤的标志物LVH对于评估心血管风险和预后至关重要.
研究的目的:
- 评估居住在英国的南亚和非洲-加勒比海人口中LVH的流行率.
- 确定LVH对这些种族群体所有原因和心血管死亡率的影响.
- 估计这些社区中未诊断的高血压的患病率.
主要方法:
- 这项研究利用了来自未来英国社区"英格兰心脏查研究" (E-ECHOES) 的数据,其中包括3200名南亚人和1858名45岁及以上的非洲-加勒比人.
- 左心室质量指数 (LVMI) 通过心声回声计量来诊断LVH.
- 考克斯回归分析用于评估LVH和死亡结果之间的关联.
主要成果:
- 49%的南亚人和64%的非洲-加勒比人患有LVH. 很大一部分 (45%的南亚人,32%的非洲-加勒比人) 患有LVH是未被诊断的高血压患者.
- LVH独立地与南亚人 (HR 1.38) 的全因死亡率增加有关,与非洲-加勒比人 (HR 1.57) 的边界相关.
- 在南亚人 (HR 2.64) 中,LVH与心血管死亡率有显著的关联,但在非洲-加勒比人 (HR 1.82) 中没有. 预计高血压患病率在南亚人中为82%,在非洲-加勒比人中为78.5%,存在大量未被诊断的患病率.
结论:
- 英国的南亚人和非洲-加勒比人患高血压的比例很高,经常未被诊断和控制不良.
- 在这些族群中, LVH 是一个常见的发现,并且与死亡率的增加有关,这突显了针对性查和管理策略的需要.
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