在B细胞淋巴瘤中瘤微环境和CAR-T细胞免疫疗法
Fengqing Cai1, Junfeng Zhang1, Hui Gao1
1Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
European journal of haematology
|September 14, 2023
概括
化学抗原受体T细胞 (CAR-T细胞) 疗法对血液癌症具有前景. 了解瘤微环境 (TME) 是克服耐药性和改善B细胞淋巴瘤中CAR-T细胞治疗疗效的关键.
科学领域:
- 免疫治疗是一种免疫疗法.
- 血液瘤学 血液瘤学
- 细胞疗法细胞疗法
背景情况:
- 化学抗原受体T细胞 (CAR-T细胞) 疗法对血液性恶性瘤有效.
- 在B细胞淋巴瘤CAR-T细胞治疗中的挑战包括响应变异性,耐药性和副作用.
- 瘤微环境 (TME) 显著影响CAR-T细胞功能和治疗结果.
研究的目的:
- 审查CAR-T细胞设计原则和TME在B细胞淋巴瘤中的作用.
- 阐明TME影响CAR-T细胞功能的机制.
- 讨论调节TME以提高CAR-T细胞疗法的疗效的策略.
主要方法:
- 关于CAR-T细胞治疗和B细胞淋巴瘤瘤微环境的现有文献的综述.
- 对TME对CAR-T细胞功能影响机制的分析.
- 讨论TME调制的新兴策略.
主要成果:
- TME包括多种成分,可以抑制CAR-T细胞活动.
- 针对免疫抑制细胞和抑制信号的策略可以改善CAR-T细胞功能.
- 提高CAR-T细胞透和在TME内的持久性对于治疗成功至关重要.
结论:
- 调节TME提供了一种有希望的方法来增强B细胞淋巴瘤的CAR-T细胞疗法.
- 需要对输液后事件和TME动态进行进一步的研究.
- 了解这些过程将导致改进的CAR-T细胞疗法和减少毒性.
相关概念视频
01:27Tumor Immunotherapy
554
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
554
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K