精神分裂症老年患者发生性痴呆症的神经病理基质:一项临床病理学研究
Shusei Arafuka1,2,3, Hiroshige Fujishiro1,3, Youta Torii1,3
1Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Psychiatry and clinical neurosciences
|September 14, 2023
概括
老年精神分裂症患者由于同时存在的神经退行性疾病或不符合当前分类的疾病而患上痴呆症. 需要进一步的临床病理学研究来了解痴呆症.
科学领域:
- 神经病理学神经病理学
- 老年精神病学是一门精神病学专业.
- 神经退行性疾病 神经退行性疾病
背景情况:
- 精神分裂症与痴呆风险增加有关,但这些患者的阿尔茨海默氏症 (AD) 发病率仍在争论中.
- 以前的研究缺乏基于当前分类的临床病理学数据,特别是在老年人中.
- 这项研究涉及老年精神分裂症患者痴呆的神经病理基础.
研究的目的:
- 研究精神分裂症老年患者痴呆的神经病理基础.
- 澄清精神分裂症和各种痴呆病理之间的关系.
- 在这个人群中识别与痴呆症相关的独特的神经病理学特征.
主要方法:
- 对32个老年精神分裂症患者的大脑进行了系统检查.
- 与痴呆相关的神经病理学的标准化半定量评估.
- 在排除符合特定标准的患者后,对患有痴呆症和没有痴呆症的患者进行临床病理学比较.
主要成果:
- 七名患者符合阿尔茨海默病 (AD) 的标准,阿尔吉罗菲尔粒细胞疾病 (AGD),勒维体痴呆症或AGD/渐进性超核性麻.
- 在剩余的25名患者中,10名患有痴呆症,但与没有痴呆症的患者没有明显的临床病理差异.
结论:
- 老年精神分裂症患者的痴呆是由于同时存在的神经退行性疾病或现有病理分类之外的疾病引起的.
- 进一步的临床病理学研究是必不可少的,超越仅仅将痴呆症视为常规神经病理学的并发症.
- 了解精神分裂症痴呆症的神经生物学需要细微的,个性化的神经病理学评估.
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