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在COVID-19相关的封锁期间,在纳塔利祖马布治疗的患者中,约翰·坎宁汉病毒血清转化率大大降低了

Chris Dwyer¹, Sifat Sharmin², Tomas Kalincik^1,2

¹Neuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia.

European journal of neurology

|September 14, 2023

概括

在接受纳塔利祖马布治疗多发性硬化症的患者中,COVID-19 限制显著降低了约翰·坎宁汉病毒 (JCV) 血清转化率. 这表明可修改的因素可能会降低这些患者的JCV风险.

科学领域:

神经免疫学神经免疫学
病毒学病毒学
流行病学流行病学

背景情况:

纳塔拉利祖马布是复发性复发性多发性硬化症 (MS) 的关键疗法.
在约翰·坎宁汉病毒 (JCV) 阳性患者中,长期使用纳塔利祖马布可能会导致渐进的多焦点白脑病变 (PML),这是一种致命的脑部感染.
定期监测JCV血清状况对于接受纳塔利祖马布治疗的患者至关重要.

研究的目的:

为了比较在COVID-19社区限制之前和期间接受natalizumab治疗的患者的JCV血清转化率.
调查广泛的公共卫生干预措施对JCV血清转化动态的影响.

主要方法:

在皇家墨尔本医院对纳塔利祖马布接受者的JCV血清状态变化的回顾性分析.
两个队列的比较:COVID前 (2012-2017,n=128) 和COVID-19封锁 (2020-2022,n=214). 这两个队列的比较是:COVID前 (2012-2017,n=128) 和COVID-19封锁 (2020-2022,n=214).
根据年龄和性别进行调整的Poisson回归建模,以评估血清转化率差异.

主要成果:

年化JCV血清转化率从COVID前的9.08%下降到COVID限制期间的2.01%,减少了4.7倍.
在COVID-19期间,JCV血清转化显著降低 (p < 0.0001).
与女性相比,男性的血清转化率高出2倍.

结论:

COVID-19限制与纳塔利祖马布治疗患者中JCV血清转化明显下降有关.
这些发现表明,封锁期间的环境或行为因素可能会减轻JCV血清转化.
对可修改的风险因素进行进一步的研究是有必要的,以减少纳塔利祖马布在MS患者的PML风险.

关键词:

在 COVID-19 疫情中,这就是JC病毒.在那个时候,她生下了Natalizumab.血清转换是一种血清转换.

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