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双重抗血小板治疗持续时间对流量转移后未破裂的动脉瘤封闭的影响:一个多中心研究
Justin E Vranic, Pablo Harker1, Christopher J Stapleton2
1Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH.
Journal of computer assisted tomography
|September 14, 2023
概括
双重抗血小板治疗 (DAPT) 持续时间影响在流量转移后内动脉瘤封闭. 缩短6个月的DAPT疗法可以优化动脉瘤的关闭并最大限度地减少并发症.
科学领域:
- 神经学 神经学
- 干预性放射学 干预性放射学
- 血管外科 血管外科
背景情况:
- 内膜流转向是内动脉瘤的关键治疗方法,需要双重抗血小板治疗 (DAPT) 来预防凝块.
- 优化DAPT持续时间对于平衡动脉瘤闭塞和预防血栓栓塞事件至关重要.
研究的目的:
- 评估DAPT类型和持续时间如何影响动脉瘤闭塞率和流转治疗后的并发症.
- 为了确定最优的DAPT策略,在内动脉瘤的内光道流转移后.
主要方法:
- 一个多中心数据库 (2012-2020年) 的回顾性分析,用于未破裂的内动脉瘤,用单个装置的流量转移来治疗.
- 对临床和放射学数据的分析,重点关注动脉瘤闭塞作为DAPT持续时间和并发症的函数.
主要成果:
- 12.7%的动脉瘤在治疗后仍然没有被排除在外. 非闭塞动脉瘤的DAPT持续时间较长 (9.4个月与7.1个月).
- DAPT持续时间显著影响了动脉瘤封闭率 (P=0.016). 短期 (≤6个月) 和长期 (>6个月) DAPT (7.9%与9.3%) 之间的并发症没有显著差异.
结论:
- 在流量转移后,缩短6个月的DAPT持续时间似乎是最合适的.
- 在6个月后转换为阿司匹林单一治疗可能会促进动脉瘤及时封闭,同时最大限度地降低血栓栓塞的风险.
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