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Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
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在KCNQ1和KCNE1通道复合体细胞外跨子单元接口的小分子I激活剂的通用结合口袋

Magnus Chan1, Harutyun Sahakyan2, Jodene Eldstrom1

  • 1Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

eLife
|September 14, 2023
PubMed
概括

研究了针对心脏IKs离子通道的药理活性剂,这对心律至关重要. 研究人员确定了关键的残留物和结合口袋动态,为新的心律失常疗法铺平了道路.

关键词:
节律失常 (arrhythmia) 是一种心律失常.生物化学 生物化学化学生物学 化学生物学心灵的心灵心灵的心灵心灵的心灵人类 人类 人类 人类 人类 人类 人类药理学 药理学 药理学 药理学 药理学通道是一种通道.

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