生物Things Explorer:一个用于生物医学API联合知识图的查询引擎
Jackson Callaghan1, Colleen H Xu1, Jiwen Xin1
1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Bioinformatics (Oxford, England)
|September 14, 2023
概括
生物Things Explorer使用联合网络服务查询虚拟生物医学知识图. 这种方法避免了维护集中式数据库,为生物医学数据探索提供了动态和分布式的解决方案.
科学领域:
- 生物医学信息学 生物医学信息学
- 计算生物学 计算生物学
- 数据科学数据科学数据科学
背景情况:
- 生物医学知识图集了各种数据,用于诸如药物发现和临床支持等应用.
- 传统的知识图需要集中集成来自多个来源的数据.
- 现有的图形分析工具有助于查询和理解复杂的生物网络.
研究的目的:
- 介绍BioThings Explorer,这是一个用于查询生物医学数据的新型应用程序.
- 提出一种联合知识图的方法,绕过了对集中数据存储库的需求.
- 在分布式生物医疗网络服务中实现自动化,多步骤查询.
主要方法:
- 开发了BioThings Explorer来查询一个虚拟的,联合的知识图.
- 利用语义精确的注释来为Web服务输入和输出提供信息.
- 网络服务的自动链接需要复杂的,多步骤的图表查询.
- 设计为一个轻量级的应用程序,用于动态信息检索.
主要成果:
- 生物Things Explorer允许查询生物医疗网络服务的分布式网络.
- 该应用程序通过链接服务调用来自动执行多步骤查询.
- 在查询时动态检索信息,不需要中央知识图.
- 促进各种生物医学应用,包括药物重新定位和目标识别.
结论:
- 生物Things Explorer提供了一种灵活可扩展的解决方案,用于访问和分析分布式生物医学数据.
- 联合,虚拟知识图的方法简化了数据集成和维护.
- 通过自动化查询链接,能够有效地探索复杂的生物关系.
相关概念视频
01:29Issues And Trends In Healthcare Delivery System
5.7K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.7K
02:26Protein Networks
4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K
01:16Bioequivalence: Overview
1.1K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
1.1K
02:04Protein-protein Interfaces
12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K
01:26Drug Discovery: Overview
8.0K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.0K