韩国人群中摄入量,SLC30A8 rs3802177多态性和结直肠癌风险:一个病例对照研究
Linh Thi Dieu Nguyen1, Madhawa Gunathilake1, Jeonghee Lee1
1Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, 323 Ilsan-Ro, Ilsandong-Gu, Goyang-Si, Gyeonggi-Do, 10408, Republic of Korea.
Journal of cancer research and clinical oncology
|September 14, 2023
概括
饮食中较高的摄入量可能会降低结肠直肠癌 (CRC) 风险. 这种关联受到SLC30A8 rs3802177遗传变异的影响,特别是在女性身上.
科学领域:
- 营养和癌症研究 营养和癌症研究
- 遗传学和流行病学
- 胃肠道瘤学 胃肠道瘤学
背景情况:
- 是一种重要的微量营养素,参与许多代谢过程和影响癌症发展的生物功能.
- 饮食中摄入量与结直肠癌 (CRC) 风险之间的确切关系仍然不完全理解.
- 遗传变异,例如SLC30A8 rs3802177多态,可能会调节营养与癌症的关联.
研究的目的:
- 调查饮食摄入量与患结直肠癌 (CRC) 的风险之间的关联.
- 检查SLC30A8 rs3802177基因变异是否会改变饮食中摄入量与CRC风险之间的关系.
- 提供关于饮食,遗传学和CRC预防之间的相互作用的见解.
主要方法:
- 进行了一项病例控制研究,涉及1431例CRC病例和2704例对照.
- 评估了饮食中的摄入量,并在参与者的子集 (1097例,1559例对照) 中对SLC30A8 rs3802177多态体进行基因定型.
- 使用无条件逻辑回归模型计算几率比率 (OR) 和95%置信区间 (CI),评估相互作用效应.
主要成果:
- 饮食中摄入量的增加显示,在整体人群中,与CRC风险有显著的反向关联 (aOR=0.80,p-trend=0.018).
- 具有SLC30A8 rs3802177 G+基因型和较高消耗的个体表现出较低的CRC风险 (p-相互作用=0.020).
- 在女性中,含摄入量较高的GG载体对CRC具有更强的保护作用 (p-相互作用=0.008).
结论:
- 饮食中的摄入与结直肠癌风险相反相关.
- 这种SLC30A8 rs3802177多态性似乎改变了这种关联,表明基因与饮食的相互作用.
- 这些发现强调了在预防CRC中的潜在作用,遗传因素影响了个体的易感性.
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