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在急性缺血性中风患者中测试抗脂抗体的现状和价值:中国的一项回顾性单中心研究

Qiqi Wang¹, Guangsong Han¹, Yuhui Sha¹

¹Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No 1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|September 14, 2023

概括

抗脂抗体 (aPL) 测试通常在年轻的女性中风患者身上进行. 这项研究表明,aPL测试也可能有利于老年患者患有无法解释的缺血性中风.

科学领域:

神经学神经学
免疫学免疫学免疫学
血管医学血管医学

背景情况:

抗脂抗体 (aPL) 是年轻和女性患者缺血性中风的确立原因.
在患有缺血性中风的老年人中aPL测试的诊断效用还不清楚.
本研究研究了在所有急性缺血性中风患者中初始aPL测试的现实应用和价值.

研究的目的:

确定急性缺血性中风患者抗脂抗体 (aPL) 测试的频率和模式.
在临床实践中确定影响aPL测试决策的因素.
评估初始aPL测试的诊断收益率,跨不同患者的人口统计和中风特征.

主要方法:

在2012年6月至2022年1月期间住院治疗的1209名急性缺血性中风患者的回顾性分析.
调查与aPL查和阳性相关的因素.
对aPL阳性和aPL阴性患者的人口统计,病因和治疗特征进行比较.

主要成果:

在1209名患者中,23.7%接受了aPL测试,其中20.2%的测试结果呈阳性.
医生更有可能测试女性,年轻的患者有较少的血管风险因素和多发性心脏病发作.
其他确定的病因的中风是阳性aPL结果的唯一重要因素 (OR 2.97).

结论:

医生在订购aPL测试时的裁量权受患者年龄,性别,血管风险因素和神经成像发现的影响.
大约四分之一的急性缺血性中风患者被测试了aPL.
aPL测试可能在患有密码性缺血性中风的老年患者中提供额外的诊断价值.

关键词:

急性缺血性中风是一次急性缺血性中风.抗脂抗体的抗脂抗体.抗脂抗体测试是一种抗脂抗体测试.缺血性中风是因为缺血性中风.一次性中风,中风.

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