在心力衰竭中,同情神经系统重新检查了同情神经系统
Filippos Triposkiadis1, Alexandros Briasoulis2, Takeshi Kitai3
1School of Medicine, European University Cyprus, 2404, Nicosia, Cyprus. ftriposkiadis@gmail.com.
Heart failure reviews
|September 14, 2023
概括
交感神经系统 (SNS) 的过度活跃越来越被认为是心力衰竭 (HF) 发展和进展的关键因素,影响了静缩和静缩功能障碍. 本综述探讨了高频管理中的SNS机制和治疗目标.
科学领域:
- 心脏病学 心脏病学
- 生理学 生理学 生理学
- 病理生理学 病理生理学
背景情况:
- 目前的神经激素模型解释了通过持续的交感神经系统 (SNS) 和氨酸-血管氨酸-氨酸系统 (RAAS) 激活的心力衰竭 (HF) 的进展.
- 这种模型主要针对具有减少射出分数 (HFrEF) 的HF,但SNS过度活性的作用更广泛.
- 有证据表明,SNS过度活跃早于HF,并且涉及HF与保留射出分数 (HFpEF) 的HF,与炎症和危险因素有关.
研究的目的:
- 提供SNS过度活动和HF之间的复杂关系的最新概述.
- 总结将SNS过度活动与HF发展和进展联系在一起的机制性途径.
- 讨论针对高频中SNS调节的治疗方法的临床影响.
主要方法:
- 文献综述和关于心力衰竭中SNS的当前研究的综合.
- 对SNS激活的血液动力学和非血液动力学影响的分析.
- 探索导致的因素,如并发症,遗传学和人口统计学.
主要成果:
- 脑神经系统过度活跃与HFrEF和HFpEF有关,通常在临床HF诊断之前.
- 通过直接和间接的途径,SNS激活有助于对心血管产生有害影响.
- 诸如HF风险因素,免疫/炎症过程,并发症,遗传学和人口统计等因素会调节HF中SNS活动.
结论:
- 脑神经系统过度活跃是导致心力衰竭的发病和进展的关键,多方面的因素.
- 了解这些复杂的关联对于开发有效的治疗策略至关重要.
- 针对SNS过度活跃是一种有前途的途径,可以改善HF管理和患者的治疗结果.
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