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MAPS-CRAFITY评分:一种新的疗效预测工具,用于用向治疗加免疫治疗治疗的不可切除的肝细胞癌

Jingzhong Ouyang¹, Yi Yang^2,3, Yanzhao Zhou¹

¹Department of Hepatobiliary and Pancreatic Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China.

Hepatology international

|September 14, 2023

概括

一个新的MAPS-CRAFITY得分有效地预测了接受向治疗加免疫治疗的肝细胞癌患者的整体存活率和瘤反应. 这种工具有助于临床医生做出明智的治疗决策,治疗不可切除的HCC.

科学领域:

肝细胞癌研究肝细胞癌研究
在瘤学瘤学.
生物标志物开发生物标志物开发

背景情况:

身体组成参数 (BCP) 与肝细胞癌 (HCC) 患者的死亡率有关.
预测HCC治疗疗效仍然是一个临床挑战.

研究的目的:

开发一个实用的评分模型,整合BCP和CRAFITY评分.
预测针对性治疗和免疫治疗的HCC患者的整体存活率 (OS) 和瘤反应.

主要方法:

对265名接受向治疗加免疫治疗的HCC患者的回顾性分析.
多变量考克斯回归以确定OS的独立预测因素.
开发和外部验证MAPS-CRAFITY评分模型.

主要成果:

根据MAPS-CRAFITY得分,包括宏血管侵袭,Child-Pugh类,肉症和CRAFITY得分,准确预测了OS (C指数为0.720-0.761).
该得分还显示了瘤反应和疾病控制的强大预测能力 (AUC 0.752-0.836).
在MAPS-CRAFITY评分 (p < 0.001) 定义的风险组之间观察到OS的显著差异.

结论:

MAPS-CRAFITY评分是预测不可切割的HCC治疗疗效的可靠和实用的工具.
这一分数可以帮助肝病学家和瘤学家对HCC患者的临床决策.

关键词:

肝细胞癌是肝细胞癌.免疫治疗是一种免疫疗法.预测预测预测的预测.萨尔科佩尼亚是什么意思萨尔科佩尼亚有针对性的治疗.

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