急性呼吸道疾病与记忆T细胞分化和其他免疫细胞变化有关,以与年龄相关的方式
Shreya S Ugale1, Tyson H Holmes1, Sofia Maysel-Auslender1
1Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA.
急性呼吸道疾病会影响免疫细胞,特别是在年轻人身上. 感染会减少B细胞,并将T细胞表型转移到效应型,而年龄会影响这些变化.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 细胞生物学 细胞生物学
背景情况:
- 对流感等呼吸道病毒的重复暴露可以随着时间的推移改变免疫细胞表型.
- 对于病毒控制至关重要的记忆T细胞区,可能会受到CD4+和CD8+T细胞反应的影响.
- 了解与年龄有关的免疫变化对于解释感染影响至关重要.
研究的目的:
- 与年龄相匹配的对照组相比,评估急性呼吸道疾病患者的免疫细胞表型.
- 调查免疫反应对呼吸道感染的年龄相关差异.
- 确定急性呼吸道疾病如何影响T细胞分化和B细胞频率.
主要方法:
- 利用飞行时间的细胞计量 (CITE-seq) 来分析周围血液免疫细胞表型.
- 将22名急性呼吸道疾病患者与22名年龄相匹配的非感染对照人进行了比较.
- 分析了免疫细胞频率和表型,包括CD4+,CD8+,B,NK和NKT细胞.
主要成果:
- 较年轻的受感染个体 (1-19岁) 显示B和NK细胞频率下降,并且具有更类似于效应体的CD4+和CD8+T细胞表型.
- 较老的感染者 (30-74岁) 与未感染的对照人群相比没有显著差异.
- 非感染个体的年龄相关变化包括原始CD4+和CD27+CD8+T细胞的减少,以及效应记忆CD8+和NKT细胞的增加.
- 在感染者和未感染者之间观察到B细胞和T细胞子集的显著年龄趋势差异.
结论:
- 急性呼吸道疾病促进T细胞分化,减少循环B细胞的数量.
- 与老年人相比,这些影响在年轻人中更为明显.
- 对呼吸道感染的免疫反应由年龄调节,突出显示了对T细胞和B细胞群体的不同影响.
更多相关视频
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
07:36Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
Published on: February 28, 2021
相关概念视频
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Cells of the Adaptive Immune Response
Cell-mediated Immune Responses
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
