一个多通道电化学传感器接口IC用于生物反应器监控
IEEE transactions on biomedical circuits and systems
|September 14, 2023
概括
本研究介绍了使用多通道电化学传感器监测生物反应器的新集成电路. 新型芯片提供精确的测量,用于实时生物过程分析,低功耗.
科学领域:
- 电气工程 电气工程
- 生物医学工程 生物医学工程
- 化学工程是化学工程的重要组成部分.
背景情况:
- 生物反应器监控需要精确的实时数据采集.
- 现有的电化学传感系统可能是复杂和耗电的.
- 集成电路为小型化和提高效率提供了一条道路.
研究的目的:
- 在生物反应器应用中引入一种用于多通道电化学传感的新型集成电路 (IC).
- 为了实现高精度和高效率的生物反应的实时监测.
- 为了证明一个低功耗,生物过程分析的综合解决方案的可行性.
主要方法:
- 使用0.18微米标准CMOS技术设计和制造一种新的IC.
- 电位计,电位计,ISFET和温度传感器通道的整合.
- 实现一个基于输送机的电流电位器,其测量范围为114dB.
- 包括超低泄漏电静电放电 (ESD) 对电位计通道的保护.
- 在基于ISFET的pH测量中使用恒压,恒流拓.
- 频道的时间复杂化到可重新配置的模拟后端进行数字转换.
主要成果:
- 该IC集成了2个电位计,2个电位计,2个ISFET和1个温度通道.
- 电位器通道实现了广泛的114 dB测量范围.
- 电位计通道显示了picoampere级的输入泄漏.
- ISFET通道提供准确的pH测量.
- 制造出来的原型显示了22μW的峰值功耗.
- 所有频道的特征都是实验性的.
结论:
- 开发的IC适用于实时生物反应监测.
- 综合的多通道传感方法提高了生物过程分析能力.
- 低功耗和高性能使IC成为先进生物反应器系统的有希望的解决方案.
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