从UPTD到ESOT:在面向潜水中监测高氧暴露
Jan Risberg1, Pieter-Jan van Ooij2, Lyubisa Matity3
1NUI, Bergen, Norway.
概括
建议采用新的指标,即等效表面氧气时间 (ESOT),以取代UPTD,用于在水母中监测肺氧毒性 (POT). 在不失去预测能力的情况下,ESOT提供了实用,准确的过氧暴露评估.
科学领域:
- 潜水医学是一门潜水医学.
- 高压生理学 高压生理学
- 毒理学 毒理学 毒理学
背景情况:
- 肺氧毒性 (POT) 是潜水中的风险,需要精确的暴露监测.
- 目前的指标,如单元肺毒性剂量 (UPTD),具有局限性.
- 一个拟议的度量,K (t2 x pO2),提供了更好的准确性,但对于操作用途来说是复杂的.
研究的目的:
- 引入和验证一种新的,实用的指标来评估潜水中的高氧暴露.
- 提出等效表面氧气时间 (ESOT) 作为UPTD和K.的替代品.
- 评估ESOT在预测POT方面的准确性和操作实用性.
主要方法:
- 定义ESOT为t x pO2 (分钟中的t,大气中的pO2),ESOT=1表示1分钟的100% O2在表面压力下.
- 将ESOT的实用性和准确性与UPTD和POT预测的K进行了比较.
- 将现有的高氧值转换为ESOT值.
主要成果:
- 与K.相比,ESOT提供了一种更实用,更直观的高氧暴露度衡量方法.
- 在POT预测中,ESOT保持了与现有指标相比的准确性.
- 对于每日高氧化物限值的ESOT确立的门:两天650元,五天500元,无限天420元.
结论:
- ESOT是用于在潜水中操作监测高氧暴露的优质指标.
- ESOT简化了暴露水平的解释,类似于UPTD.
- 拟议的ESOT指标提高了在潜水操作期间管理POT风险的安全性和实用性.
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