一个随机试验,针对急性一氧化碳中毒的一次或三次高压氧气治疗
Lindell K Weaver1,2, Kayla Deru3, Susan Churchill1
1Hyperbaric Medicine and Wound Care, Intermountain Medical Center, Murray, UT and LDS Hospital, Salt Lake City, Utah U.S.
概括
三次高压氧气 (HBO2) 疗程与一次一氧化碳 (CO) 中毒后的疗程相比,没有减少神经心理后果. 在两组治疗中,六周和六个月的认知结果在两组治疗中都相似.
科学领域:
- 神经学 神经学
- 毒理学 毒理学 毒理学
- 紧急医疗 紧急医疗
背景情况:
- 高压氧 (HBO2) 用于急性一氧化碳 (CO) 中毒,但最佳剂量尚不清楚.
- 在CO中毒后,神经心理后果很常见,影响认知功能和生活质量.
研究的目的:
- 为了比较急性CO中毒患者在六周和六个月的神经心理结果,接受三次HBO2会话或一个HBO2会话与两个假会话.
- 为了确定强化HBO2疗法是否能改善CO中毒后的认知恢复.
主要方法:
- 一个双盲,假控制的随机试验,涉及急性CO中毒患者.
- 参与者在24小时内接受了三次HBO2会话或一次HBO2会话,然后在24小时内接受了两次虚假会话.
- 在治疗后六周和六个月评估神经心理后果.
主要成果:
- 该研究因注册无效而提前停止,分析了72名患者.
- 六周神经心理后续的发生率在1HBO2组为50%,在3HBO2组为55% (p=0.80).
- 六个月后,这些比例分别为42%和46% (p=0.76),两组之间没有显著差异.
结论:
- 在急性CO中毒后的一到三次HBO2会话之间没有观察到神经心理后果的显著差异.
- 较高的后续效应率可能与测试重试效应或风险因素 (如年龄和中毒持续时间) 有关.
- 在CO中毒后脑损伤很常见,表现为认知和情感症状.
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