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Updated: Jun 22, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

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一个安全机制使得C. elegans在老化过程中具有组织特异性抵抗蛋白质聚合的能力

Raimund Jung1, Marie C Lechler1,2, Ana Fernandez-Villegas3

  • 1German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.

PLoS biology
|September 14, 2023
PubMed
概括

衰老会损害蛋白质质量控制,导致蛋白质聚合. 一种涉及细胞内病原体反应组件的新型安全机制,准了溶酶体降解的蛋白质,以防止聚合.

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相关概念视频

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...