非O ABO血型的基因型不同于它们与Plasmodium falciparum rozetting和严重疟疾的关联
D Herbert Opi1,2, Carolyne M Ndila1, Sophie Uyoga1
1Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
PLoS genetics
|September 14, 2023
概括
与"单剂量"基因型 (AO,BO) 相比,具有"双剂量"非O型血型 (AA,BB,AB) 个体面临的严重疟疾风险更高. 这与更大的Plasmodium falciparum宿主红血细胞红有关.
科学领域:
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 血型O通过减少Plasmodium falciparum宿主红血细胞 (RBC) 章来提供对严重疟疾的保护.
- 在非O血型 (AO,BO,AA,BB,AB) 之间,严重疟疾的风险差异尚不清楚.
研究的目的:
- 调查"双剂量"非O ABO基因型 (AA,BB,AB) 与"单剂量"异构细胞 (AO,BO) 相比,是否会增加严重疟疾风险和红细胞罗列形成.
主要方法:
- 对肯尼亚儿童进行了一项病例对照研究.
- 在体外粘附试验中,用于分析具有不同 ABO 基因型的 Plasmodium falciparum 寄生虫 rozetting.
主要成果:
- 与血型O相比,双剂量基因型显示严重疟疾的几率比率更高.
- 与OO相比,ABO基因型AA和AB表现出与P. falciparum相比显著更大的红,而AO和BO没有.
结论:
- ABO基因型显著影响了P. falciparum的生长.
- 双剂量非O基因型的严重疟疾风险比单剂量异构菌的风险更大,支持这一假设.
更多相关视频
10:22Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
8.9K
09:57Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay
Published on: August 6, 2020
6.5K
相关概念视频
The ABO Blood Group
1.8K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
1.8K
Blood Types
17.8K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
17.8K
Blood Typing
1.2K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.2K
Blood Transfusion and Agglutination
10.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.9K
Rh Blood Group
1.5K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.5K
Blood Transfusion
603
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
603
