根据年龄确定基线尿液抗菌水平:一项前性观察性研究
Jeffrey M Caterino1, Julie A Stephens2, Randell Wexler3
1Department of Emergency Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA.
概括
老年人与年轻人相比,尿道人类β-defensin-2 (hBD-2) 水平较低,影响先天免疫力和潜在的尿路感染诊断. 其他抗微生物 (AMP) 根据年龄没有显著差异.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
背景情况:
- 抗微生物 (AMP) 对尿路天生的免疫非常重要.
- 了解AMP与年龄相关的差异对于老年人尿路感染易感性和生物标志物发展至关重要.
研究的目的:
- 为了研究尿道抗微生物 (AMP) 水平与年龄相关的差异.
- 在年轻和年长的成年人之间比较人类中性粒细胞1-3 (HNP 1-3),人类α-defensin-5 (HD-5),人类β-defensin-2 (hBD-2) 和cathelicidin (LL-37) 的水平.
主要方法:
- 对308名成年人 (≥18岁) 的横截面研究.
- 酶相关免疫吸收试验 (ELISA) 用于量化尿路AMP.
- 未调整和多变量线性回归模型分析了年龄和AMP水平之间的关联.
主要成果:
- 与年轻人相比,老年人 (≥65岁) 的尿液hBD-2水平明显较低 (p<0.001).
- 对于HNP 1-3,HD-5或LL-37没有观察到与年龄相关的显著差异.
- 尿液白细胞化酶,血液和污染与特定的AMP水平有关.
结论:
- 在老年人中,尿液中的hBD-2水平较低,这表明与年龄相关的天生的免疫力变化.
- 在未感染的个体中,尿液中的HNP 1-3,HD-5和LL-37水平不会随年龄显著变化.
- 这些发现对使用尿路AMP作为老年人群中尿路感染的诊断标记有意义.
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