装有维他素的聚乙烯糖醇) 甲基乙醇移植的奇托/酸纳米颗粒:制备,物理化学性质和体外释放行为
Rangrong Yoksan1,2, Pawika Towongphaichayonte1
1Department of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok, Thailand.
Journal of the science of food and agriculture
|September 14, 2023
概括
这项研究成功地制造了带有维特辛载荷的聚乙烯糖醇 (PEG) 甲基乙醇移植的奇托/酸纳米颗粒. 这些纳米粒子增强了维特克辛的作用.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物化学 生物化学
背景情况:
- 维特克辛是一种生物活性黄类化合物,具有潜在的健康益处,但其水溶性较差,限制了其口服生物利用性.
- 封装策略对于改善像维捷克辛这样的溶解不良化合物的输送和有效性至关重要.
研究的目的:
- 为了将维特辛封装在聚乙烯糖醇) 甲基以太移植的奇托 (mPEG-g-CTS) /酸 (ALG) 聚电解质复合纳米颗粒中.
- 为了评估特征,负载能力,抗氧化活性,和在体外释放的概况的 vitexin-loaded纳米颗粒.
主要方法:
- 通过两步的油在水乳液和离子凝工艺制造带有维他素的mPEG-g-CTS/ALG纳米颗粒.
- 使用富里叶变换的红外光谱学,紫外可见光谱学和X射线衍射的表征.
- 评估纳米粒子大小,表面电荷,负载能力,封装效率,抗氧化活性和体外释放动力学.
主要成果:
- 成功合成了具有负面表面电荷 (-27至-38mV) 的球形纳米粒子 (50-200nm).
- 实现了高负载能力 (4-60%) 和封装效率 (50-100%),具有显著的抗氧化活性.
- 封装组件的热稳定性和氧化降解延迟,以pH取决于体外释放.
结论:
- 装有维泰克素的mPEG-g-CTS/ALG纳米颗粒成功地制造出没有苛刻的交叉连接器.
- 开发的纳米颗粒适合于口腔肠道特异性输送系统,改善维特的胃肠道消化.
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