素受体对抗性:在老年和疾病中规范睡眠架构
Jarrah O-Z J Kron1, Ryan J Keenan1,2, Daniel Hoyer1,3,4
1The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia;
Annual review of pharmacology and toxicology
|September 14, 2023
概括
老年人和患有阿尔茨海默病的人睡眠不好. 素受体对抗剂在改善睡眠和潜在地减缓这些人群中痴呆症进展方面表现有前途.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 睡眠质量和数量随着年龄的增长而下降,这增加了老年人 (>65岁) 睡眠障碍的风险.
- 睡眠障碍和阿尔茨海默氏症 (AD) 或相关痴呆症之间存在双向关系.
- 素/海波克雷丁系统调节着清醒状态,在衰老和阿尔茨海默病中失调.
研究的目的:
- 评估素受体对抗剂 (ORA) 对老年人和痴呆症患者睡眠障碍的疗效和耐受性.
- 探索ORAs在缓解与年龄相关的睡眠衰退及其与痴呆症的联系方面的潜力.
- 确定ORA干预睡眠/清醒失调的最佳时间.
主要方法:
- 对老年人群和痴呆症患者ORA使用的临床研究的综述.
- 对素系统在衰老和阿尔茨海默病中的作用的分析.
- 评估ORA作为催眠药的疗效及其安全性概况.
主要成果:
- 在老年人和痴呆症患者中,ORAs是有效的催眠药,类似于它们在成人中的效果.
- 在这些人群中,ORAs通常被很好地容忍.
- 早期对ORAs的干预可以恢复健康的睡眠模式,并减少痴呆症相关的蛋白质积累.
结论:
- 在老化和痴呆症中治疗失眠时,ORAs是一个有前途的治疗选择.
- 早期向素系统可能会改善睡眠行为并影响痴呆症的进展.
- 在衰老和痴呆症中改善睡眠为患者,护理人员和医疗保健系统提供了显著的好处.
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