在共体细菌上集成COAL层的双氧化物,以实现向瘤抑制和免疫疗法
Cheng Zhou1, Jiafei Chen2, Bingzhu Zheng1,3
1State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310058, China.
ACS applied materials & interfaces
|September 14, 2023
概括
这项研究引入了一种新的生物混合系统,将细菌和纳米粒子结合起来用于癌症治疗. 该系统通过产生氧化和激活免疫反应,有效地消除瘤和转移.
科学领域:
- 生物材料科学 生物材料科学
- 癌症免疫疗法癌症免疫疗法
- 纳米技术 纳米技术
背景情况:
- 向治疗和免疫疗法为癌症治愈提供了希望.
- 像Propionibacterium acnes (PA) 这样的细菌可以被设计为向免疫疗法.
- 层状双氧化物 (LDH) 可用于修改细菌性质.
研究的目的:
- 设计和合成一种生物混合系统 (PA@LDH),用于联合向和免疫治疗.
- 调查PA@LDH系统对固体瘤的体外和体内疗效.
- 探索抗瘤活性背后的机制,包括氧化生成和免疫调节.
主要方法:
- 合成的PA@LDH是通过对PA涂上NO3 - - 间接合金合金LDH.
- 对降低病原性和改变PA的表面电荷进行评估的LDH涂层.
- 评估了LDH对瘤部位的PA释放的酸反应降解.
- 研究了PA将酸盐转化为氧化 (NO) 的能力及其与超氧化基 (O2·−) 的反应.
- 分析了释放的离子在抑制超氧化物脱酶 (SOD) 和提高O2·−水平中的作用.
- 研究了PA诱导的M2-to-M1巨细胞两极分化和免疫反应.
- 进行了体外和体内实验,以评估瘤消除和转移抑制.
主要成果:
- 该PA@LDH系统证明了有效的瘤定居和氧化 (NO) 生产.
- NO的产生导致有毒反应性物种 (ONOO−) 的形成,诱导瘤细胞的亡.
- 释放的离子抑制了SOD,增加了O2·−并增强了抗瘤作用.
- 暴露于PA促进了M2-to-M1巨细胞的两极分化和持续的免疫反应.
- 在体外和体内研究证实了显著消除固体瘤和抑制转移.
结论:
- 开发的生物混合系统 (PA@LDH) 提供了一种用于同时针对性和免疫治疗的新策略.
- 这种方法利用细菌脱和纳米粒子衍生的离子来产生强大的抗瘤活性.
- 生物混合系统在治疗固体瘤和预防转移方面显示出显著的潜力.
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