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塞斯特林2/Keap1/Nrf2通路调节了与交通相关的PM2.5和水溶性提取物诱导的肺表皮中的粘液过分分泌

Jiayu Tian1, Xin Wang2, Hao Shi1

  • 1Department of Environmental Health, School of Public Health, Shanxi Medical University, 56 Xinjian South Road, 030001 Taiyuan, Shanxi, China; Center for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, 56 Xinjian South Road, 030001 Taiyuan, Shanxi, China; Key Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, China.

Ecotoxicology and environmental safety
|September 14, 2023
PubMed
概括

与交通相关的细颗粒物 (PM2.5) 和其提取物通过增加粘液,使喘恶化. 这通过Sestrin2/Keap1/Nrf2通路发生,导致氧化应激和粘液产生.

关键词:
喘 喘 是一种粘液过分分泌 粘液过分分泌塞斯特林2 / 凯普1 / 诺夫2与交通相关的PM{2.5)在水中溶解的提取物

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