介面强相互作用启用级联纳米酶用于亡-费洛亡协同疗法
Lineng Wei1, Ziyu Wang1, Xiuxin Lu1
1Department of Research, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, China.
Journal of colloid and interface science
|September 14, 2023
概括
贵金属纳米酶,如Ir-Co(OH) 2,通过产生反应性氧物种 (ROS) 显示出对癌症治疗的希望. 这种新材料通过与最小剂量的协同性亡-亡疗法增强了抗瘤作用.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 贵金属纳米酶在癌症治疗中受到探索,原因是瘤微环境 (TME) 中的活性氧物种 (ROS) 生成.
- 尽量减少剂量是减少纳米酶潜在系统生物毒性的关键.
- 开发具有增强治疗活动的高效纳米酶至关重要.
研究的目的:
- 为增强癌症治疗,合成和描述在Co(OH) 2纳米片 (Ir6.2-Co(OH) 2) 上的Ir纳米集群.
- 研究新型纳米酶的类似酶的活动和协同治疗效应.
- 探索在贵金属氧化物接口上的电子相互作用在治疗应用中的潜力.
主要方法:
- 将 (Ir) 纳米团固定在含有特定Ir含量 (6.2 wt%) 的氧化 (Co(OH) 2) 纳米板上.
- 评估Ir6.2-Co(OH) 2纳米酶的过氧化酶 (POD),酶 (CAT) 和谷氨过氧化酶 (GSH-Px) 类活动.
- 评估体外和体内瘤抗瘤疗效通过亡-亡协同疗法,包括ROS生成,H2O2补充和GSH耗尽.
主要成果:
- 合成的Ir6.2-Co(OH) 2纳米酶表现出显著的POD,CAT和GSH-Px类活动.
- 在Ir-O-Co接口上观察到强烈的电子相互作用,有助于增强ROS生成和酶调节.
- 在体外和体内研究均证实,通过协同性亡-费洛亡疗法显著增强了抗瘤疗效.
结论:
- Ir6.2-Co(OH) 2纳米酶在用于癌症治疗的协同亡-亡疗法中表现出高效率.
- 利用贵金属和氧化物之间的电子相互作用是开发先进纳米酶的有希望的策略.
- 这种方法具有显著的潜力,用于高效的协同作用的癌症疗法,具有优化的纳米酶剂量.
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