抗生素可能干扰头部和部状细胞癌患者的尼沃卢马布疗效
Reio Ueta1,2, Hiroo Imai3,4, Ken Saijo1,2
1Department of Medical Oncology, Tohoku University Hospital, Sendai, Japan.
Oncology
|September 14, 2023
概括
发现抗生素的使用显著降低了免疫检查点抑制剂 (ICI) nivolumab 的有效性,在患有头部和部状细胞癌 (SCC) 的患者中. 这项研究强调了抗生素对ICI治疗结果的负面影响.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 药理学 药理学是指药理学的学科.
背景情况:
- 头部和部平细胞癌 (HNSCC) 患者通常接受免疫检查点抑制剂 (ICI).
- 之前的研究表明,抗生素可能会降低ICI在各种癌症中的疗效.
- 抗生素对HNSCC的ICI疗效的影响仍在调查中.
研究的目的:
- 追溯评估抗生素使用对尼沃卢马布 (ICI) 在HNSCC患者疗效的影响.
- 为了比较在nivolumab治疗期间接受抗生素和未接受抗生素的HNSCC患者之间的治疗结果.
主要方法:
- 用尼沃卢马布 (2017-2021) 治疗的HNSCC患者的医疗记录的回顾性审查.
- 患者接受抗生素 (口服或静脉注射) 从一个月前开始nivolumab直到第一个疗效评估被归类为抗生素治疗.
- 两组之间的反应率 (RR),无进展生存率 (PFS) 和整体生存率 (OS) 的比较.
主要成果:
- 这项研究包括了45名接受抗生素治疗的患者和19名未接受抗生素治疗的患者.
- 未接受抗生素治疗的组显示出更高的响应率 (42.1%与23.7%) 和更长的中位数PFS (5.8与3.2个月) 和OS (18.4与8.4个月).
- 与抗生素治疗小组相比,未接受抗生素治疗的小组的无进展生存时间明显更长.
结论:
- 在接受尼沃卢马布的头部和部SCC患者中,抗生素治疗与无进展生存时间显著缩短有关.
- 这些发现表明抗生素和尼沃卢马布在HNSCC中的有效性之间存在负面相互作用.
- 进一步的研究可能是有必要的,以探索这种相互作用背后的机制.
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