目前的见解和早期出现的2型糖尿病的新兴趋势
Shivani Misra1, Calvin Ke2, Shylaja Srinivasan3
1Division of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; Department of Diabetes and Endocrinology, Imperial College Healthcare NHS Trust, London, UK.
The lancet. Diabetes & endocrinology
|September 14, 2023
概括
早期发病的2型糖尿病在全球范围内正在上升,增加了微血管并发症和早期死亡的风险. 为了在患有这种疾病的年轻人中制定有效的管理策略,需要更多的研究.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 早期发病的2型糖尿病 (T2D) 在童年/青春期被诊断在全球范围内迅速增加,与肥胖率的上升有关.
- 这种情况与晚些时候出现的T2D相比,具有更高的微血管并发症,心血管事件和过早死亡的不明原因风险.
- 患有早期T2D的妇女面临着不良妊娠结果的风险增加,这有助于未来的多发性疾病负担显著增加.
研究的目的:
- 提供关于早期2型糖尿病的见解和新兴趋势的当代更新,重点关注青少年和年轻成年人群.
- 突出了解和管理T2D在年轻成年人 (19-39岁) 的研究差距,目前的证据中代表性不足.
- 强调需要优先干预,以扭转早期T2D发病的趋势.
主要方法:
- 本综述综合了研究中的证据,包括患有2型糖尿病早期发病的青少年和年轻成年人.
- 它分析了当前的见解,新兴趋势,并确定了该人口的管理和病理生理学的研究缺口.
- 该审查考虑了影响年轻人疾病进展和治疗疗效的因素.
主要成果:
- 早期发病的T2D与严重并发症和死亡率不成比例地更高的风险有关.
- 患有T2D的年轻人 (19-39岁) 的特征不如儿科病例,面临独特的自我管理挑战和耻辱.
- 目前的护理模式对于青少年和年轻人来说似乎不够理想,这表明对量身定制策略的需求至关重要.
结论:
- 早期发病的2型糖尿病是一个重大的,不断增长的全球健康挑战,需要紧急关注和优先干预.
- 量身定制的预防策略,包括生活方式干预措施,可能对成功至关重要,特别是考虑到肥胖和种族等风险因素.
- 进一步的研究对于开发和验证2型糖尿病青少年和年轻成年人最佳管理策略至关重要,以减轻长期并发症并改善结果.
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