怀孕前草甘暴露对母亲的影响
Shanthi Ganesan1, Aileen F Keating1
1Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
Toxicology and applied pharmacology
|September 14, 2023
概括
母亲暴露于草甘 (GLY) 可能会影响卵巢功能,在暴露后的六个月内观察到母体卵泡数量减少. 这项研究调查了GLY.
科学领域:
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
- 环境健康 环境健康
背景情况:
- 妇产草甘 (GLY) 暴露对出生结果的影响尚未完全理解.
- 怀孕前GLY暴露对母体和后代的影响需要调查.
研究的目的:
- 在小鼠中评估孕前孕产妇对草甘暴露的表型和分子效应.
- 为了确定GLY暴露是否会影响母的生殖成功和后代的发展.
- 为了研究GLY暴露后持续的卵巢分子变化.
主要方法:
- 在交配之前,雌性小鼠接受了口服草甘 (GLY) 或盐液 (CT) 治疗20周.
- 生殖参数 (怀孕指数,子大小,幼存活率) 在三轮繁殖中进行了评估.
- 卵巢组织分析了蛋白质变化 (LC-MS/MS) 和卵泡数量在暴露停止后的六个月.
主要成果:
- 草甘暴露改变了繁殖周期的妊娠指数,并在孕妇中增加了脏重量.
- 在后代中没有观察到直接的表型影响.
- 在怀孕前的GLY暴露导致二次卵泡数量减少,卵巢蛋白质的显著变化,包括基因组蛋白,在老年女性.
结论:
- 母亲在怀孕前暴露于草甘可以引起暂时和持续的卵巢影响.
- 改变的卵巢蛋白质组和减少的卵泡数量表明潜在的长期生殖后果.
- 基斯蛋白修饰可能是草甘对卵巢毒性的关键途径.
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