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化沉积模型打印参数对平板电脑分解时间的影响:实验设计研究
Klemen Kreft1,2, Tijana Stanić2, Petra Perhavec2
1University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Slovenia.
Acta pharmaceutica (Zagreb, Croatia)
|September 14, 2023
概括
研究了融合沉积建模 (FDM) 药品的3D打印. 填充百分比和喷嘴直径显著影响平板电脑分解时间,而层高度没有,确保工艺的稳定性.
科学领域:
- 制药技术 制药技术 制药技术
- 通过3D打印,可以实现3D打印.
- 材料科学 材料科学 材料科学
背景情况:
- 沉积建模 (FDM) 是一个有前途的3D打印技术,用于制药应用.
- 了解工艺参数对于控制3D打印固体剂型的质量至关重要.
- FDM参数对平板电脑性能的影响,特别是分解时间的影响,仍未得到充分研究.
研究的目的:
- 调查FDM过程参数对3D打印平板电脑分解时间的影响.
- 开发一款用于平板电脑分解的预测统计模型.
- 评估固体剂型的FDM印刷工艺的稳定性.
主要方法:
- 使用实验设计 (DOE) 方法研究FDM打印参数.
- 调查的关键参数包括灌装百分比,灌装模式,喷嘴直径和层高度.
- 使用了定制开发的FDM 3D打印机和Simplify 3D软件.
主要成果:
- 填充百分比是最重要的参数,可将分解时间抛物线式增加.
- 更大的喷嘴直径延长了由于更厚的挤出线条而导致的分解时间.
- 充填模式在分解过程中极大地影响了内部结构的机械阻力.
- 层高度没有显著影响解体时间.
结论:
- 可以优化FDM过程参数,特别是灌装百分比和喷嘴直径,以控制平板电脑的分解时间.
- 开发了一个强大的统计模型 (R2=0.928,Q2=0.847) 来预测分解.
- 灌装模式和层高度影响了质量和分解均性,表明可以实现工艺控制.
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