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成年1型糖尿病患者转换为闭环系统的葡萄糖代谢结果
Giuseppe Papa1, Rossella Cannarella2, Rosita A Condorelli3
1Unit of Metabolic and Endocrine Disease, "Centro Catanese di Medicina e Chirurgia" Clinic, Catania, Italy.
Diabetes research and clinical practice
|September 14, 2023
概括
转换为混合闭环 (HCL) 和高级混合闭环 (AHCL) 系统显著改善了1型糖尿病 (T1D) 患者的葡萄糖控制. 患者对这些自动胰岛素输送 (AID) 技术的满意度很高.
科学领域:
- 内分泌学和新陈代谢学
- 生物医学工程 生物医学工程
- 糖尿病 技术 技术
背景情况:
- 1型糖尿病 (T1D) 的管理传统上依赖于在开放循环系统中每天多次注射 (MDI) 或连续皮下胰岛素输注 (CSII).
- 自动化胰岛素输送 (AID) 系统,包括混合闭环 (HCL) 和高级混合闭环 (AHCL),代表了糖尿病管理的重大进步.
- 对以前未接触过这项技术的患者转换为AID系统的影响的评估对于了解其现实世界的有效性和安全性至关重要.
研究的目的:
- 在过渡到HCL和AHCL系统后,评估T1D患者对AID技术原始的糖代谢结果.
- 将AID系统的有效性和安全性与之前的MDI或CSII (开放循环) 管理进行比较.
- 评估患者对实施的AID技术的满意度.
主要方法:
- 这是一项为期12个月的前性观察性研究,在两个中心进行.
- 涉及54名T1D患者 (19-65岁) 之前在开放循环中接受了MDI或CSII治疗.
- 主要评估的重点是转换到AID系统后的血糖控制指标和安全参数的变化.
主要成果:
- 在研究结束时,观察到HbA1c水平的显著改善.
- 目标范围中的时间 (TIR,70-180 mg/dL) 从50.5%大幅增加到73.6% (p < 0.001).
- 时间高于范围 (TAR) 和时间低于范围 (TBR) 显著下降,同时降低了葡萄糖水平的变化系数 (CV) (p < 0.001 对于 TAR/TBR,p < 0.05 对于 CV).
结论:
- 切换到HCL/AHCL系统导致艾滋病原始T1D患者的糖代谢控制显著且安全地改善.
- 这些先进的AID系统在提高血糖参数方面表现出相当大的有效性.
- 患者对新的AID治疗方式表示高度满意.
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