在 rotifer Brachionus plicatilis 中的甲基的代谢途径
Hangyu Lin1, Xiaodong Mao1, Yanlin Wei1
1College of Fisheries, Southwest University, Chongqing 400715, China; Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, 400715, China.
The Science of the total environment
|September 14, 2023
概括
甲基 (MeHg) 积聚在虫中,主要是在消化器官中. 这项研究显示了MeHgg.
科学领域:
- 环境毒理学环境毒理学
- 海洋生物学 海洋生物学
- 生物化学 生物化学
背景情况:
- 甲基 (MeHg) 在水生食物网中生物放大.
- 了解主要水生生物中的MeHg积累和新陈代谢至关重要.
研究的目的:
- 为了研究MeHg在 rotifer Brachionus plicatilis中的体内积聚点.
- 探索MeHg在B. plicatilis中的代谢调节和毒性机制.
主要方法:
- 使用聚合诱导排放素 (AIEgen) 进行MeHg的光成像.
- 采用代谢学来分析对MeHg暴露的代谢变化.
- 直接暴露 (溶解的MeHg) 与间接暴露 (通过食物) 的比较.
主要成果:
- MeHg积聚在特定的组织中,如状冠状,消化器官和脚踏腺.
- 直接暴露于MeHg会提高ABC输送的调节,而间接暴露会影响碳和氨基酸代谢.
- 干扰氨酸生物合成表明增加了能源生产,以对抗MeHg毒性.
结论:
- 根据B. plicatilis. 的暴露途径,MeHg积累部位和代谢反应不同.
- 代谢干扰,包括ABC载体的丰富和氨基酸路径的改变,是MeHg毒性的关键.
- 这项研究提供了关于MeHg对海洋无脊椎动物的影响的见解.
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