探索各种小麦提取物在促进烧伤愈合方面的有效性:比较分析
Mai A M Ahmed1, Marwa F Ali2, Nesma M Mohamed3
1Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
Journal of ethnopharmacology
|September 14, 2023
概括
小麦提取物,特别是冷水提取物,通过减少炎症和促进组织再生,在老鼠中加速伤口愈合. 这项研究调查了小麦在烧伤治疗中的民族药理学潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 伤口愈合 治愈 伤口愈合
- 皮肤病学 皮肤病学
背景情况:
- 尽管取得了进展,但烧伤管理仍然是一个挑战,需要多学科的方法.
- 小麦在治疗皮肤疾病,包括烧伤方面具有传统历史,特别是在意大利.
- 在小麦对烧伤的治疗作用背后的精确机制尚未完全理解.
研究的目的:
- 研究各种小麦提取物在促进烧伤伤愈合方面的有效性.
- 评估这些提取物对烧伤的总体,本病学和免疫学影响.
- 探索小麦作为治疗烧伤的天然疗法的潜力.
主要方法:
- 维斯塔雄性大鼠被分为五组:对照组 (盐水),梅博,冷水提取物,热水提取物和甲醇提取物.
- 实验组接受了烧伤后的局部治疗,而对照组接受了盐水.
- 在21天的时间内评估了伤口愈合,随后进行了生物化学,细胞因子,组织病理学和免疫组织化学分析.
主要成果:
- 组织病理学分析显示,与盐水和Mebo.相比,在所有接受小麦提取物治疗的组中,炎症明显减少.
- 冷水提取物组显示出最显著的上皮和颗粒组织形成.
- 所有测试的小麦分枝提取物都对烧伤伤愈合产生了积极的影响.
结论:
- 冷水和甲醇小麦提取物促进了老鼠的快速有效的伤口愈合.
- 冷水提取物的有效性归因于其丰富的和化合物的度.
- 小麦提取物代表了治疗烧伤治疗的有前途的治疗方案.
相关概念视频
01:19Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
01:22Burn Injuries
2.5K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.5K
01:28Phases of Wound Repair
6.1K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.1K
01:24Inflammatory Response II: Inflammatory Exudate and Tissue Repair
5.0K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
5.0K