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视网膜神经退行变化与多发性硬化症中过度活跃膀综合征之间的关系
Berna Sahan1, Asli Koskderelioglu2, Okan Akmaz3
1Medicana International Izmir Hospital, Department of Ophthalmology, Izmir, Turkey.
Photodiagnosis and photodynamic therapy
|September 14, 2023
概括
多发性硬化症 (MS) 患者的过度活性膀 (OAB) 与更大的神经轴损伤有关. 具体来说,OAB与减少的视网膜神经纤维层 (pRNFL) 和黄斑结节细胞内状层 (mGCIPL) 厚度相关,特别是在下象限.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 多发性硬化症 (MS) 可以影响视神经和视网膜.
- 过度活性膀 (OAB) 是MS患者常见的并发症.
- 神经轴损伤是MS病理的一个关键特征.
研究的目的:
- 为了比较患有OAB和没有OAB的MS患者视神经和视网膜的神经损伤.
- 调查OAB严重程度与视网膜和视神经健康的具体措施之间的关系.
- 在MS患者中识别OAB的潜在指标.
主要方法:
- 患有多发性硬化症的患者根据OAB严重程度分为两组,使用OAB-V8问卷.
- 评估扩展残疾状况尺度 (EDSS),视力敏度,眼内压力,外皮皮质视网膜神经纤维层 (pRNFL) 厚度和黄斑结核细胞内状层 (mGCIPL) 厚度.
- 在OAB和非OAB组之间比较这些参数.
主要成果:
- 总共分析了来自65名多发性硬化症患者的120只眼睛.
- 具有较高OAB分数的患者 (2组) 的EDSS分数明显更高.
- 第二组的pRNFL厚度 (平均,上,下) 和mGCIPL厚度 (上,上鼻,下腔,上腔四分之一) 在统计学上显著减少.
结论:
- 在没有视神经炎的多发性硬化患者中,OAB发生率随着EDSS得分的提高而增加.
- 在OAB和mGCIPL和prNFL的稀释之间存在显著的关联.
- 下象限pRNFL稀薄是与MS患者的OAB相关的关键因素.
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