临床艾滋病毒治疗中患者报告的结果:丹麦单中心多阶段混合方法研究的协议
Olivia Borchmann1, Nina Weis2,3, Ann-Brit Eg Hansen2,3
1Department of Infectious Diseases, Hvidovre Hospital, Copenhagen University Hospital, Hvidovre, Denmark oliviaborchmann@gmail.com.
BMJ open
|September 14, 2023
概括
患者报告结果 (PROs) 可以改善HIV-1 (PWH) 感染者的健康相关生活质量 (HRQoL). 这项研究开发和评估了HIV护理中的PRO,旨在提高患者的治疗结果和医疗保健提供者的意识.
科学领域:
- 艾滋病毒/艾滋病研究研究
- 患者报告的结果 (PROs)
- 医疗保健服务研究 医疗服务研究
背景情况:
- 患有HIV-1 (PWH) 的人体验到与健康相关的生活质量 (HRQoL) 的下降.
- 患者报告的结果 (PROs) 提供了一种改善HIV护理中HRQoL关注的手段.
- 开发和实施PRO对于加强以患者为中心的艾滋病毒管理至关重要.
研究的目的:
- 开发,实施和评估PRO在艾滋病毒护理中的使用.
- 确定相关的PRO领域,并评估PRO使用的障碍/好处.
- 评估PRO使用对医疗保健提供者 (HCP) 意识和文档的影响.
主要方法:
- 混合方法研究,包括定性 (焦点小组,采访) 和定量 (调查,前后分析) 副研究.
- 基于定性发现的患者报告结果指标 (PROM) 的开发.
- 评估 PWH 愿意与 PRO 接触的程度,以及 HCP 对 PRO 结果的认识.
主要成果:
- 定性数据为PROM的设计提供了信息.
- 量化数据评估了PWH与PROMs的参与.
- 分析比较了PRO实施前和之后的HCP文档化率.
结论:
- 专业人员有潜力将艾滋病毒护理重定向到改善HRQoL.
- 该研究提供了关于在艾滋病毒环境中开发和实施PRO的见解.
- 进一步的研究可以建立在这些发现的基础上,以优化PRO在临床实践中的整合.
相关概念视频
01:20Study Designs in Epidemiology
263
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
263
01:11Clinical Trials: Overview
3.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.0K
01:16Clinical Trials
6.8K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.8K