循环节律与癌症的关系
Chandrabose Selvaraj1, Sher Zaman Safi2, Rajendran Vijayakumar3
1Centre for Transdisciplinary Research, Department of Pharmacology, Saveetha College of Dental and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India.
Advances in protein chemistry and structural biology
|September 14, 2023
概括
循环节律由分子钟调节,对健康至关重要. 这些节律和时钟基因的破坏与癌症的发展和进展有关,提供了新的治疗点.
科学领域:
- * 时代生物学和分子生物学
- * 癌症研究和病原发生.
背景情况:
- * 昼夜节律是与24小时昼夜周期同步的内生生物振荡器.
- * 分子昼夜钟,包括时钟基因和时钟控制的基因,调节生理过程.
- * 昼夜节律失调显著影响哺乳动物生理学和人类健康,特别是在癌症等疾病状态下.
研究的目的:
- *阐明昼夜节律的基本组成部分.
- * 探索昼夜节律在癌症发病和进展中的作用.
- *讨论临床影响,现有治疗策略,以及癌症治疗中昼夜调节的未来目标.
主要方法:
- * 关于昼夜生物学和癌症的现有文献的全面审查.
- *分析基底的分子机制昼夜时钟的功能及其破坏.
- * 整合临床观察和治疗干预的数据.
主要成果:
- * 时钟基因的异常表达破坏了细胞周期控制和细胞亡,促进了基因组的不稳定性和致癌性.
- * 循环时钟功能障碍是癌症发展和进展的重要因素.
- * 调节时钟基因为新型癌症疗法提供了一个有希望的途径.
结论:
- *了解昼夜节律对于理解癌症生物学至关重要.
- * 准昼夜时钟为癌症治疗提供了一个新的治疗策略.
- * 需要对时钟药物和治疗点进行进一步的研究,以获得临床应用.
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