普雷加巴林与 gabapentin 在治疗与背部手术失败综合征相关的神经病痛的有效性
Laith Thamer Al-Ameri1, Mohammed Emad Shukri1, Ekhlas Khalid Hameed1
1Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.
Journal of Korean Neurosurgical Society
|September 14, 2023
概括
普雷加巴林和 gabapentin 有效地管理失败的背部手术综合征 (FBSS) 中的神经病痛. 在这项临床试验中,与 gabapentin 相比,普雷加巴林显示出优异的疼痛减轻效果.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 失败的背部手术综合征 (FBSS) 是脊柱手术的普遍并发症,标志着持续的慢性疼痛.
- 目前FBSS疼痛的管理策略多样化,需要进行比较疗效研究.
研究的目的:
- 为了比较Pregabalin和Gabapentin在管理与FBSS相关的神经病痛方面的疗效.
- 为了评估FBSS患者治疗Pregabalin或Gabapentin的疼痛减轻.
主要方法:
- 一个双盲,随机,比较的临床试验 (NCT05324761) 涉及两个并行手臂:普雷加巴林和 gabapentin.
- 疼痛评估在基线和终点使用视觉模拟量表 (VAS).
- 统计分析包括T测试,协差分析和对对比.
主要成果:
- 普雷加巴林和 gabapentin 均显著降低了疼痛 (p=0.001 在两组).
- 与 gabapentin (p=0.001) 相比,普雷加巴林在统计学上显示出更好的疼痛减轻效果 (p=0.001).
- 患者的性别,狭窄位置和手术类型并没有显著影响减轻疼痛的结果.
结论:
- 普雷加巴林和 gabapentin 是有效和安全的治疗神经病痛在FBSS.
- 普雷加巴林在FBSS患者的疼痛缓解中提供了一种更有效的选择,无论性别如何.
相关概念视频
01:23Peripheral Artery Disease V: Postoperative Nursing Management
12
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
12
01:25Analgesia and Pain Management
652
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
652
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
672
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
672