儿童患有与Omicron变异相关的急性脑炎/脑病变的危险因素
Chong-Wei Huang1, Jainn-Jim Lin2, Chen-Yen Kuo1
1Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
儿童COVID-19相关的急性脑炎/脑病变与炎症有关,而不是直接的病毒入侵. 高龄,高中性粒细胞计数和高甲激素是关键的危险因素.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 台湾的Omicron BA.2变种激增增加了儿科急性脑炎/脑病变病例.
- 与COVID-19相关的神经系统并发症,包括脑炎,在儿童中预后较差.
- 有限的研究存在于儿童COVID-19相关脑炎/脑病变的危险因素,病理生理学和预后.
研究的目的:
- 描述儿科COVID-19相关的急性脑炎/脑病变的临床表现.
- 确定与儿童神经系统并发症相关的危险因素.
- 探索炎症在中枢神经系统功能障碍中的潜在作用.
主要方法:
- 确诊SARS-CoV-2感染的儿科患者的潜在招生.
- 将患者分为急性脑炎/脑病变,发烧性或轻度疾病组.
- 收集人口,临床和实验室数据进行分析.
主要成果:
- 在288名COVID-19患者中,13.2%患有急性脑炎/脑病变.
- 常见的症状包括昏迷,发作和意识受损.
- 确定了独立的危险因素:年龄超过3岁,绝对中性粒细胞数量升高,以及高甲水平.
结论:
- 儿童的COVID-19相关脑炎/脑病变往往缺乏直接的病毒入侵.
- 研究结果表明,中性粒细胞介导的炎症反应有助于中枢神经系统功能障碍.
- 年龄较大,中性粒细胞增加和前素与更糟糕的结果有关.
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