3级严重的肝损伤二次到Pembrolizumab
Paola López-Marte1, Bárbara Rosado-Carrión2
1University of Puerto Rico, School of Medicine, Division of Gastroenterology Research, San Juan, Puerto Rico.
Puerto Rico health sciences journal
|September 14, 2023
概括
作为检查点抑制剂的 pembrolizumab 有效治疗无法切除的癌症,但可能导致严重的肝损伤. 这一案例凸显了迅速识别和管理这种免疫疗法引起的免疫媒介性肝损伤的迫切需要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 布罗利祖马布是一种广泛使用的免疫检查点抑制剂,用于不可切除的恶性瘤.
- 虽然有效,但免疫媒介的副作用,包括肝损伤,是越来越令人担忧的.
- 与pembrolizumab相关的肝毒性可能是严重的和危及生命的.
研究的目的:
- 在患有喉癌的患者中报告二次布罗利祖马布严重肝损伤的病例.
- 强调在接受pembrolizumab的患者中识别和管理免疫媒介性肝损伤的重要性.
主要方法:
- 一个85岁的男性患有第三阶段喉癌的病例报告.
- 严重肝损伤的临床表现和诊断工作.
- 关于布罗利祖马布诱导的肝毒性的文献综述.
主要成果:
- 患者患有严重的肝损伤,归因于 pembrolizumab 治疗.
- 肝损伤需要及时的医疗照顾和管理.
- 这一案例强调了免疫治疗可能导致严重的肝脏不良事件的可能性.
结论:
- 布罗利祖马布诱导的肝损伤是癌症患者的重大临床问题.
- 警和早期诊断对于管理可能危及生命的肝毒性至关重要.
- 医生之间的意识对于在免疫治疗期间的最佳患者护理至关重要.
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