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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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生殖中心的输出是由B细胞中依赖HELLS的DNA甲基化维护维持的

Clara Cousu1, Eléonore Mulot1, Annie De Smet1

  • 1Université Paris Cité, CNRS UMR 8253, INSERM U1151, Institut Necker Enfants Malades, F-75015, Paris, France.

Nature communications
|September 14, 2023
PubMed
概括

酶,淋巴细胞特异性 (HELLS) 蛋白质对于维持DNA甲基化和幽默免疫是至关重要的. 它的缺乏加速了生殖中心B细胞的衰变,并损害了记忆B细胞的产生.

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