相关实验视频

Updated: Jun 20, 2026

Isolation and Derivation of Mouse Embryonic Germinal Cells
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Isolation and Derivation of Mouse Embryonic Germinal Cells

Published on: October 22, 2009

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单层平台在体外产生和净化原始的胚胎状细胞,提供了对人类胚胎谱规范的洞察力

Sivakamasundari Vijayakumar1,2, Roberta Sala1,3, Gugene Kang1,3

  • 1Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Nature communications
|September 14, 2023
PubMed
概括

研究人员开发了一种简化的单层方法,在3.5天内从人类多能干细胞 (hPSC) 产生人类原始生殖细胞样细胞 (PGCLC),从而推进不孕症研究.

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Differentiation of Newborn Mouse Skin Derived Stem Cells into Germ-like Cells In vitro09:47

Differentiation of Newborn Mouse Skin Derived Stem Cells into Germ-like Cells In vitro

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Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells12:06

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

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相关概念视频

Fertilization01:38

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
Cleavage and Blastulation01:33

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...